TRNA-guanine transglycosylase
From Proteopedia
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<StructureSection load='1p0e' size='350' side='right' caption='Structure of tRNA-guanine transglycosylase complex with queuine precursor (PDB entry [[1p0e]])' scene=''> | <StructureSection load='1p0e' size='350' side='right' caption='Structure of tRNA-guanine transglycosylase complex with queuine precursor (PDB entry [[1p0e]])' scene=''> | ||
| - | '''tRNA-guanine transglycosylase''' (TGT) is involved in the post-transcriptional modification of tRNA. TGT is involved in the replacement of guanine-34 by queuine precursor (preQ1) in the anticodon of tRNA. In archaebacteria TGT (ATGT) catalyzes the introduction of archaeosin precursor (preQ0) into the D-loop of tRNA. | + | '''tRNA-guanine transglycosylase''' (TGT) is involved in the post-transcriptional modification of tRNA. TGT is involved in the replacement of guanine-34 by queuine precursor (preQ1) in the anticodon of tRNA<ref>PMID:11680848</ref>. In archaebacteria TGT (ATGT) catalyzes the introduction of archaeosin precursor (preQ0) into the D-loop of tRNA. |
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| + | == Structural highlights == | ||
| + | TGT overall structure is of a Tim barrel. A structural Zn+2 ion is tetrahedrally coordinated in the C-terminal subdomain. The active site contains preQ1<ref>PMID:14523925</ref>. | ||
</StructureSection> | </StructureSection> | ||
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**[[1j2b]] – PhATGT + tRNA-Val<BR /> | **[[1j2b]] – PhATGT + tRNA-Val<BR /> | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:52, 26 September 2016
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3D structures of tRNA-guanine transglycosylase
Updated on 26-September-2016
References
- ↑ Nonekowski ST, Garcia GA. tRNA recognition by tRNA-guanine transglycosylase from Escherichia coli: the role of U33 in U-G-U sequence recognition. RNA. 2001 Oct;7(10):1432-41. PMID:11680848
- ↑ Brenk R, Stubbs MT, Heine A, Reuter K, Klebe G. Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design. Chembiochem. 2003 Oct 6;4(10):1066-77. PMID:14523925 doi:10.1002/cbic.200300644
