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3jai
From Proteopedia
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| - | ''' | + | ==Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon== |
| - | + | <StructureSection load='3jai' size='340' side='right' caption='[[3jai]], [[Resolution|resolution]] 3.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3jai]] is a 87 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JAI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JAI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jag|3jag]], [[3jah|3jah]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jai FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jai OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jai RCSB], [http://www.ebi.ac.uk/pdbsum/3jai PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/U3KPD5_RABIT U3KPD5_RABIT]] Binds to the 23S rRNA.[RuleBase:RU000576] [[http://www.uniprot.org/uniprot/ERF1_HUMAN ERF1_HUMAN]] Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons.<ref>PMID:7990965</ref> [[http://www.uniprot.org/uniprot/G1SS70_RABIT G1SS70_RABIT]] May play a role during erythropoiesis through regulation of transcription factor DDIT3.[HAMAP-Rule:MF_03122] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Brown, A]] | [[Category: Brown, A]] | ||
| - | [[Category: | + | [[Category: Hegde, R S]] |
[[Category: Murray, J]] | [[Category: Murray, J]] | ||
| - | [[Category: Hegde, R.S]] | ||
[[Category: Ramakrishnan, V]] | [[Category: Ramakrishnan, V]] | ||
| + | [[Category: Shao, S]] | ||
| + | [[Category: Abce1]] | ||
| + | [[Category: Erf1]] | ||
| + | [[Category: Ribosome]] | ||
| + | [[Category: Termination]] | ||
Revision as of 14:57, 12 August 2015
Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UGA stop codon
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Categories: Oryctolagus cuniculus | Brown, A | Hegde, R S | Murray, J | Ramakrishnan, V | Shao, S | Abce1 | Erf1 | Ribosome | Termination
