4r8h
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein== |
| - | + | <StructureSection load='4r8h' size='340' side='right' caption='[[4r8h]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r8h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R8H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SP1:6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL'>SP1</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r8h OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r8h RCSB], [http://www.ebi.ac.uk/pdbsum/4r8h PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[Category: | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Cann, M J]] | ||
| + | [[Category: Glover, L C]] | ||
| + | [[Category: Hodgson, D R.W]] | ||
| + | [[Category: Korhonen, H J]] | ||
| + | [[Category: McLeish, T C.B]] | ||
[[Category: Pohl, E]] | [[Category: Pohl, E]] | ||
| - | [[Category: | + | [[Category: Rodgers, T L]] |
| - | + | [[Category: Townsend, P D]] | |
| - | + | [[Category: Wilson, M R]] | |
| - | [[Category: | + | [[Category: Transcription]] |
| - | [[Category: | + | [[Category: Transcription factor]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
| - | + | ||
Revision as of 14:14, 22 July 2015
The role of protein-ligand contacts in allosteric regulation of the Escherichia coli Catabolite Activator Protein
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