5a5i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cytochrome 2C9 P450 inhibitor complex== | |
| - | + | <StructureSection load='5a5i' size='340' side='right' caption='[[5a5i]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A5I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XI1:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)CYCLOHEXYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>XI1</scene></td></tr> | |
| - | [[ | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a5j|5a5j]]</td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5i OCA], [http://pdbe.org/5a5i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a5i RCSB], [http://www.ebi.ac.uk/pdbsum/5a5i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5i ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Groot, M J.de]] | ||
[[Category: Phillips, C]] | [[Category: Phillips, C]] | ||
| - | [[Category: | + | [[Category: Skerratt, S E]] |
| + | [[Category: Oxidoreductase]] | ||
Revision as of 06:48, 10 September 2016
Cytochrome 2C9 P450 inhibitor complex
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