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5bxt
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==LNBase in complex with LNB-NHAcAUS== |
| + | <StructureSection load='5bxt' size='340' side='right' caption='[[5bxt]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5bxt]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BXT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BXT FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WS:N-{[(1R,2R,3R,7S,7AR)-1,2,7-TRIHYDROXYHEXAHYDRO-1H-PYRROLIZIN-3-YL]METHYL}ACETAMIDE'>4WS</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5bxp|5bxp]], [[5bxs|5bxs]], [[5bxr|5bxr]]</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lacto-N-biosidase Lacto-N-biosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.140 3.2.1.140] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bxt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bxt OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5bxt RCSB], [http://www.ebi.ac.uk/pdbsum/5bxt PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The synthesis of potent inhibitors for lacto-N-biosidases and X-ray structural characterization of these compounds in complex with BbLNBase is described. | ||
| - | + | Gaining insight into the catalysis by GH20 lacto-N-biosidase using small molecule inhibitors and structural analysis.,Hattie M, Ito T, Debowski AW, Arakawa T, Katayama T, Yamamoto K, Fushinobu S, Stubbs KA Chem Commun (Camb). 2015 Aug 27. PMID:26312778<ref>PMID:26312778</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lacto-N-biosidase]] | ||
| + | [[Category: Arakawa, T]] | ||
[[Category: Fushinobu, S]] | [[Category: Fushinobu, S]] | ||
[[Category: Ito, T]] | [[Category: Ito, T]] | ||
| - | [[Category: | + | [[Category: Distal gut]] |
| + | [[Category: Human milk oligosaccharide]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Tim barrel]] | ||
Revision as of 11:09, 9 September 2015
LNBase in complex with LNB-NHAcAUS
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