5c0m
From Proteopedia
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| - | ''' | + | ==Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide== |
| - | + | <StructureSection load='5c0m' size='340' side='right' caption='[[5c0m]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c0m]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C0M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4WQ:(2S)-2-AMINO-7,7-DIMETHYLOCTANOIC+ACID'>4WQ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c0m OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c0m RCSB], [http://www.ebi.ac.uk/pdbsum/5c0m PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SGF29_HUMAN SGF29_HUMAN]] Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA-type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation.<ref>PMID:19103755</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Cerovina, T]] | ||
[[Category: Dong, A]] | [[Category: Dong, A]] | ||
| + | [[Category: Edwards, A M]] | ||
[[Category: Min, J]] | [[Category: Min, J]] | ||
| - | [[Category: | + | [[Category: Structural genomic]] |
[[Category: Tempel, W]] | [[Category: Tempel, W]] | ||
| - | [[Category: Arrowsmith, C.H]] | ||
[[Category: Xu, C]] | [[Category: Xu, C]] | ||
| - | [[Category: | + | [[Category: Carba containing peptide]] |
| - | [[Category: | + | [[Category: Sgc]] |
| - | [[Category: | + | [[Category: Sgf29]] |
| + | [[Category: Tandem tudor domain]] | ||
| + | [[Category: Transcription]] | ||
Revision as of 12:28, 1 July 2015
Crystal structure of SGF29 tandem tudor domain in complex with a Carba containing peptide
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