Urokinase
From Proteopedia
(Difference between revisions)
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| - | {{STRUCTURE_1c5w| PDB=1c5w | SIZE=400| SCENE= |right|CAPTION=Human urokinase short chain (grey) and catalytic domain (green) complex with iodobenzine inhibitor and citrate, [[1c5w]] }} | ||
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| - | '''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178). | ||
| + | <StructureSection load='1c5w' size='340' side='right' caption='Human urokinase short chain (grey) and catalytic domain (green) complex with iodobenzine inhibitor and citrate, [[1c5w]]' scene='' > | ||
| + | == Function == | ||
| + | '''Urokinase''' (UK) is a serine protease whose principal substrate is plasminogen – the inactive zymogen of plasmin<ref>PMID:15454079</ref>. UK consists of 3 domains: ligand-binding domain and kringle and growth factor domains. Prourokinase (PUK) is the inactive zymogen of UK which becomes active by proteolytic cleavage into catalytic domain (residues 179-431) and short chain (residues 156-178). | ||
| + | </StructureSection> | ||
== 3D Structures of urokinase == | == 3D Structures of urokinase == | ||
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**[[4dw2]] - hUK B chain catalytic domain + antibody<br /> | **[[4dw2]] - hUK B chain catalytic domain + antibody<br /> | ||
}} | }} | ||
| - | + | ==References== | |
| + | <references /> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:03, 11 December 2016
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3D Structures of urokinase
Updated on 11-December-2016
References
- ↑ Dhar G, Sanders ER, Johnson RC. Architecture of the hin synaptic complex during recombination: the recombinase subunits translocate with the DNA strands. Cell. 2004 Oct 1;119(1):33-45. PMID:15454079 doi:http://dx.doi.org/10.1016/j.cell.2004.09.010
