Thiol:disulfide interchange protein

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<StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with Mes (PDB code [[1eej]])' scene=''>
<StructureSection load='1eej' size='340' side='right' caption='E. coli DsbC complex with Mes (PDB code [[1eej]])' scene=''>
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'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase. DsbC acts as a proofreader and breaks the incorrectly formed disulfide bonds. It contains the CXXC motif. DsbC is activated by the N terminal domain of DsbD.
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'''Thiol:disulfide interchange protein''' (DsbC) is a prokaryotic disulfide bond isomerase. <br />
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*'''DsbC''' acts as a proofreader and breaks the incorrectly formed disulfide bonds. It contains the CXXC motif. DsbC is activated by the N terminal domain of DsbD.<br />
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*'''DsbD''' transfers electrons from the cytoplasmic thioredoxin to the periplasm thus maintaining the active site of DsbC, DsbE and DsbG in a reduced state.<br />
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*'''DsbE''' catalyzes the reductive step in the assembly of periplasmic c-type cytochrome. <br />
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*'''DsbG''' provides reducing equivalents to rescue oxidatively-damaged secreted proteins.
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== Function ==
== Function ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* Thiol:disulfide interchange protein (DsbC)
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**[[1eej]], [[1tjd]] – EcDsbC – ''Escherichal coli'' <BR />
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**[[1g0t]], [[1jzo]] – EcDsbC (mutant) <BR />
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**[[2iyj]] – EcDsbC N terminal<BR />
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**[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR />
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**[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR />
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**[[4fyb]], [[4fyc]] – DsbC – ''Helicobacter pylori'' <BR />
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**[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR />
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**[[4ilf]] – StDsbC (mutant) <BR />
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*Thiol:disulfide interchange protein (DsbD)
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**[[1l6p]], [[1jpe]], [[3pfu]] – EcDsbD N terminal<BR />
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**[[1uc7]], [[2fwe]], [[2fwf]] [[2fwg]], [[2fwh]] – EcDsbD C terminal<BR />
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**[[4ip1]], [[4ip6]] – EcDsbD C terminal (mutant)<BR />
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**[[1vrs]] – EcDsbD N terminal (mutant) + C terminal (mutant)<BR />
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**[[1z5y]] – EcDsbD N terminal (mutant) + EcDsbE soluble domain (mutant)<BR />
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**[[2k0r]] – NmDsbD N terminal – ''Neisseria meningitis''<BR />
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**[[2k9f]] – NmDsbD N terminal + thoredoxin<BR />
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*Thiol:disulfide interchange protein (DsbE)
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**[[2b1k]], [[3k8n]] – EcDsbE <BR />
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**[[2b1l]], [[2g0f]] – EcDsbE (mutant) <BR />
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**[[3kh7]], [[3kh9]] – DsbE soluble domain – ''Pseudomonas aeruginosa''<BR />
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*Thiol:disulfide interchange protein (DsbG)
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[[1eej]], [[1tjd]] – EcDsbC – ''Escherichal coli'' <BR />
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**[[1v57]], [[1v58]] – EcDsbG <BR />
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[[1g0t]], [[1jzo]] – EcDsbC (mutant) <BR />
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**[[2h0g]], [[2h0h]], [[2h0i]] – EcDsbG (mutant) <BR />
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[[2iyj]] – EcDsbC N terminal<BR />
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**[[2iy2]] – EcDsbG N terminal<BR />
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[[1jzd]] – EcDsbC (mutant) + DsbD N terminal<BR />
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}}
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[[1t3b]] – DsbC – ''Haemophilus influenzae'' <BR />
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[[4fyb]], [[4fyc]] – DsbC – ''Helicobacter pylori'' <BR />
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[[4i5q]] – StDsbC – ''Salmonella typhimurium''<BR />
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[[4ilf]] – StDsbC (mutant) <BR />
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== References ==
== References ==
<references/>
<references/>

Revision as of 10:43, 28 June 2015

E. coli DsbC complex with Mes (PDB code 1eej)

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3D Structures of thiol:disulfide interchange protein

Updated on 28-June-2015

References

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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