TIR domain-containing adapter protein
From Proteopedia
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(New page: <StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain (PDB code 3ub2)' scene=''> '''TIR domain-containing adaptor protein''' (TIRAP) is one of ...) |
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| - | + | <StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain complex with dithiothreitol (PDB code [[3ub2]])' scene=''> | |
| - | <StructureSection load='3ub2' size='340' side='right' caption='MAL adaptor protein TIR domain (PDB code [[3ub2]])' scene=''> | + | |
'''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response. | '''TIR domain-containing adaptor protein''' (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: '''MyD88, MAL, TRIF, TRAM and SARM'''. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response. | ||
Revision as of 08:38, 5 July 2015
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3D Structures of TIR domain-containing adaptor protein
Updated on 05-July-2015
