P63
From Proteopedia
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(New page: <StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA (PDB code 3us0)' scene=''> '''P63''' is a tumor protein belonging to the P53 fam...) |
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| - | <StructureSection load='3us0' size='340' side='right' caption='P63 DNA-binding domain complex with DNA (PDB code [[3us0]])' scene=''> | + | |
'''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. | '''P63''' is a tumor protein belonging to the P53 family. It is a multi-isoform protein required for epidermal development. One isoform of P63 is involved in skin development and stem/progenitor cell regulation. Another isoform functions in apoptosis. P63 domains structure is similar to that of P53 with an N-terminal transactivation domain (TAD) followed by proline-rich region, DNA-binding domain (DBD) and tetramerization domain. In addition, the P63 contains an additional C-terminal region with SAM (Sterile a-Motif) and transactivation inhibitory domains. The SAM domain is involved in protein-protein interactions. | ||
Revision as of 09:55, 5 July 2015
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3D Structures of P63
Updated on 05-July-2015
