Rhodopsin kinase
From Proteopedia
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<StructureSection load='3c4x' size='340' side='right' caption='Bovine rhodopsin kinase complex with ATP (stick model), Mg+2 and Cl- ions (PDB code [[3c4x]])' scene=''> | <StructureSection load='3c4x' size='340' side='right' caption='Bovine rhodopsin kinase complex with ATP (stick model), Mg+2 and Cl- ions (PDB code [[3c4x]])' scene=''> | ||
| - | '''Rhodopsin kinase''' (RK) is an enzyme which catalyzes the conversion of rhodopsin and ATP to phosphorhodopsin and ADP. RK is retina-specific and the phosphorylation of rhodopsin initiates the phototransduction cascade. The rapid desensitization permits rapid adaptation to changes in illumination. RK is inhibited by the neuronal calcium-binding protein recoverin. | ||
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== Function == | == Function == | ||
| + | '''Rhodopsin kinase''' (RK) is an enzyme which catalyzes the conversion of rhodopsin and ATP to phosphorhodopsin and ADP. RK is retina-specific and the phosphorylation of rhodopsin initiates the phototransduction cascade<ref>PMID:3040978</ref>. The rapid desensitization permits rapid adaptation to changes in illumination. RK is inhibited by the neuronal calcium-binding protein recoverin. | ||
== Disease == | == Disease == | ||
| - | Mutations in RK are associated with night blindness. | + | Mutations in RK are associated with night blindness<ref>PMID:9020843</ref>. |
== Relevance == | == Relevance == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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[[3c4y]] – bRK – bovine <br /> | [[3c4y]] – bRK – bovine <br /> | ||
Revision as of 07:53, 9 August 2016
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3D Structures of rhodopsin kinase
Updated on 09-August-2016
3c4y – bRK – bovine
3t8o – bRK (mutant)
3c4w, 3c4x – bRK + ATP
3c4z, 3c50, 3c51 – bRK + ADP
3qc9 – bRK (mutant) + ADP
4l9i – bRK + paroxetine
4pni – bRK + inhibitor
4wbo – bRK + almexanox
References
- ↑ Kuhn H, Wilden U. Deactivation of photoactivated rhodopsin by rhodopsin-kinase and arrestin. J Recept Res. 1987;7(1-4):283-98. PMID:3040978
- ↑ Yamamoto S, Sippel KC, Berson EL, Dryja TP. Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness. Nat Genet. 1997 Feb;15(2):175-8. PMID:9020843 doi:http://dx.doi.org/10.1038/ng0297-175
