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4qnq
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263== | |
| - | + | <StructureSection load='4qnq' size='340' side='right' caption='[[4qnq]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4qnq]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QNQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QNQ FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1XJ:4-(4-{[2-(4-CHLOROPHENYL)-5,5-DIMETHYLCYCLOHEX-1-EN-1-YL]METHYL}PIPERAZIN-1-YL)-N-[(4-{[(2R)-4-(MORPHOLIN-4-YL)-1-(PHENYLSULFANYL)BUTAN-2-YL]AMINO}-3-[(TRIFLUOROMETHYL)SULFONYL]PHENYL)SULFONYL]BENZAMIDE'>1XJ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qnq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qnq OCA], [http://pdbe.org/4qnq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4qnq RCSB], [http://www.ebi.ac.uk/pdbsum/4qnq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4qnq ProSAT]</span></td></tr> |
| - | [[ | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2CL1_RAT B2CL1_RAT]] Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.<ref>PMID:8662675</ref> <ref>PMID:7828536</ref> <ref>PMID:18250306</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Korste, A]] | ||
[[Category: Stoll, R]] | [[Category: Stoll, R]] | ||
| - | [[Category: | + | [[Category: Vetter, I R]] |
| + | [[Category: Alpha-helical protein]] | ||
| + | [[Category: Apoptosis]] | ||
| + | [[Category: Apoptosis-apoptosis inhibitor complex]] | ||
Revision as of 17:04, 18 August 2017
Crystal Structure Analysis of full-length Bcl-XL in complex with the inhibitor ABT-263
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