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5c33

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'''Unreleased structure'''
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==Crystal Structure of Mouse Ryanodine Receptor 2 SPRY1 Domain==
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<StructureSection load='5c33' size='340' side='right' caption='[[5c33]], [[Resolution|resolution]] 1.21&Aring;' scene=''>
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The entry 5c33 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c33]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C33 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C33 FirstGlance]. <br>
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Authors: Yuchi, Z., Van Petegem, F.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene></td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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Description: Crystal Structure of Mouse Ryanodine Receptor 2 SPRY1 Domain
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5c30|5c30]]</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c33 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c33 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c33 RCSB], [http://www.ebi.ac.uk/pdbsum/5c33 PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/RYR2_MOUSE RYR2_MOUSE]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.<ref>PMID:10473538</ref> <ref>PMID:9628868</ref> <ref>PMID:21098440</ref> <ref>PMID:20431056</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Petegem, F Van]]
[[Category: Yuchi, Z]]
[[Category: Yuchi, Z]]
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[[Category: Van Petegem, F]]
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[[Category: Contractile protein]]
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[[Category: Ligand-binding]]
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[[Category: Spry]]

Revision as of 20:20, 5 August 2015

Crystal Structure of Mouse Ryanodine Receptor 2 SPRY1 Domain

5c33, resolution 1.21Å

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