Cullin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1ldj' size='340' side='right' caption='Human cullin-1 complex with ring box protein 1 (PDB code 1ldj)' scene=''> '''Cullins''' are hydrophobic scaffold protein...) |
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| - | + | <StructureSection load='1ldj' size='340' side='right' caption='Human cullin-1 (grey) complex with ring box protein 1 (green) and Zn+2 ion (grey) (PDB code [[1ldj]])' scene=''> | |
| - | <StructureSection load='1ldj' size='340' side='right' caption='Human cullin-1 complex with ring box protein 1 (PDB code [[1ldj]])' scene=''> | + | |
'''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex. The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> | '''Cullins''' are hydrophobic scaffold proteins for E3 ubiquitin ligases. They combine with ring box proteins (RBX) to form the CRL complex. The CRL complex is essential in targeting proteins to ubiquitin-mediated destruction. Cullin-1 to 7 are part of the multi-subunit ubiquitin complex. Conjugation of cullin to NEDD8 modulates the activation of the CRL.<br /> | ||
*'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<br /> | *'''Cullin-1''' is part of the SCF (Skp-cullin-F-box containing) complex which catalyzes the ubiquitination of proteins.<br /> | ||
Revision as of 07:44, 9 July 2015
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3D Structures of cullin
Updated on 09-July-2015
