437d
From Proteopedia
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|PDB= 437d |SIZE=350|CAPTION= <scene name='initialview01'>437d</scene>, resolution 1.6Å | |PDB= 437d |SIZE=350|CAPTION= <scene name='initialview01'>437d</scene>, resolution 1.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> | + | |LIGAND= <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=GTP:GUANOSINE-5'-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=437d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=437d OCA], [http://www.ebi.ac.uk/pdbsum/437d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=437d RCSB]</span> | ||
}} | }} | ||
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[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
[[Category: Su, L.]] | [[Category: Su, L.]] | ||
| - | [[Category: MG]] | ||
| - | [[Category: NA]] | ||
[[Category: pseudoknot]] | [[Category: pseudoknot]] | ||
[[Category: rna]] | [[Category: rna]] | ||
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[[Category: viral frameshifting]] | [[Category: viral frameshifting]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:37:16 2008'' |
Revision as of 02:37, 31 March 2008
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| , resolution 1.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF AN RNA PSEUDOKNOT FROM BEET WESTERN YELLOW VIRUS INVOLVED IN RIBOSOMAL FRAMESHIFTING
Overview
Many viruses regulate translation of polycistronic mRNA using a -1 ribosomal frameshift induced by an RNA pseudoknot. A pseudoknot has two stems that form a quasi-continuous helix and two connecting loops. A 1.6 A crystal structure of the beet western yellow virus (BWYV) pseudoknot reveals rotation and a bend at the junction of the two stems. A loop base is inserted in the major groove of one stem with quadruple-base interactions. The second loop forms a new minor-groove triplex motif with the other stem, involving 2'-OH and triple-base interactions, as well as sodium ion coordination. Overall, the number of hydrogen bonds stabilizing the tertiary interactions exceeds the number involved in Watson-Crick base pairs. This structure will aid mechanistic analyses of ribosomal frameshifting.
About this Structure
437D is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Minor groove RNA triplex in the crystal structure of a ribosomal frameshifting viral pseudoknot., Su L, Chen L, Egli M, Berger JM, Rich A, Nat Struct Biol. 1999 Mar;6(3):285-92. PMID:10074948
Page seeded by OCA on Mon Mar 31 05:37:16 2008
Categories: Protein complex | Berger, J M. | Chen, L. | Egli, M. | Rich, A. | Su, L. | Pseudoknot | Rna | Triplex | Viral frameshifting
