TIR domain-containing adapter protein

TIR domain-containing adaptor protein (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: MyD88, MAL, TRIF, TRAM and SARM. The TIR domain, which is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.

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Structural highlights