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Profilin
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I complex with α-actin and VASP protein poly-Pro peptide (PDB code 2pbd)' scene=''> '''Profilin''' (PFN)...) |
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| - | + | <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I (green) complex with α-actin (pale green), VASP protein poly-Pro peptide (olive), ATP (stick model) and Ca+2 ion (PDB code [[2pbd]])' scene=''> | |
| - | <StructureSection load='2pbd' size='340' side='right' caption='Human profilin I complex with α-actin | + | |
'''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. | '''Profilin''' (PFN) enhances actin growth by binding to monomeric actin, thus becoming profilactin. PFN catalyzes the exchange of poorly polymerizing ADP-actin to readily polymerizing ATP-actin. PFN binds to poly-L-proline, thus it recruits the actin monomers to proline-rich proteins like VASP, which enhance the growing of actin polymers. PFN-I is expressed in most tissues while PFN-II is expressed in brain and kidney. PFN was found in all eukaryotes. | ||
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**[[2jkg]] – PfPFN + poly-Pro peptide <br /> | **[[2jkg]] – PfPFN + poly-Pro peptide <br /> | ||
**[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br /> | **[[1awi]], [[1cf0]], [[1cjf]] – hPFN + poly-Pro peptide <br /> | ||
| - | **[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide | + | **[[2pav]], [[2pbd]], [[3chw]] – hPFN + α-actin + VASP poly-Pro peptide + ATP <br /> |
*Profilin II | *Profilin II | ||
Revision as of 08:20, 15 July 2015
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3D Structures of profilin
Updated on 15-July-2015
