Wiskott-Aldrich syndrome protein
From Proteopedia
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| - | <StructureSection load='2a3z' size='340' side='right' caption='Human WASP WH2 domain complex with α-actin | + | <StructureSection load='2a3z' size='340' side='right' caption='Human WASP WH2 domain (pink) complex with α-actin (grey), DNAse I (green), ATP (stick model), Ca+2 and Mg+2 ions, glycerol and formic acid (PDB code [[2a3z]])' scene=''> |
'''Wiskott-Aldrich syndrome protein''' (WASP) is involved in nucleating of new F-actin. In the autoinhibited form of WASP a region of the N-terminal interacts with a region of its C-terminal. This interaction is disrupted by CDC42 and phosphatidylinositol 4,5-bisphosphate (PIP2) resulting in the active WASP. '''N-WASP''' (Neural WASP) belongs to the WASP family of proteins. Human N-WASP stimulates the actin-nucleating activity. N-WASP induces actin polymerization in the Shigella bacterium. This bacterium causes dysentery. | '''Wiskott-Aldrich syndrome protein''' (WASP) is involved in nucleating of new F-actin. In the autoinhibited form of WASP a region of the N-terminal interacts with a region of its C-terminal. This interaction is disrupted by CDC42 and phosphatidylinositol 4,5-bisphosphate (PIP2) resulting in the active WASP. '''N-WASP''' (Neural WASP) belongs to the WASP family of proteins. Human N-WASP stimulates the actin-nucleating activity. N-WASP induces actin polymerization in the Shigella bacterium. This bacterium causes dysentery. | ||
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**[[1t84]] – hWASP autoinhibited + wiskostatin - NMR<br /> | **[[1t84]] – hWASP autoinhibited + wiskostatin - NMR<br /> | ||
**[[1cee]] – hWASP GTPase binding domain + CDC42 - NMR<br /> | **[[1cee]] – hWASP GTPase binding domain + CDC42 - NMR<br /> | ||
| - | **[[2a3z]] – hWASP WH2 domain + α-actin + DNAse I<br /> | + | **[[2a3z]] – hWASP WH2 domain + α-actin + DNAse I + ATP<br /> |
**[[2ot0]] – hWASP C terminal + fructose-bisphosphate aldolase<br /> | **[[2ot0]] – hWASP C terminal + fructose-bisphosphate aldolase<br /> | ||
**[[2k42]] – hWASP CRIB domain + ESPFU - NMR<br /> | **[[2k42]] – hWASP CRIB domain + ESPFU - NMR<br /> | ||
Revision as of 10:08, 15 July 2015
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3D Structures of Wiskott-Aldrich syndrome protein
Updated on 15-July-2015
