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5bwy

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'''Unreleased structure'''
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==Structure of proplasmepsin II from Plasmodium falciparum, Space Group P43212==
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<StructureSection load='5bwy' size='340' side='right' caption='[[5bwy]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5bwy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5BWY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5BWY FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5bwy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5bwy OCA], [http://pdbe.org/5bwy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5bwy RCSB], [http://www.ebi.ac.uk/pdbsum/5bwy PDBsum]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
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The entry 5bwy is ON HOLD until Paper Publication
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Crystal structure of the novel aspartic proteinase zymogen proplasmepsin II from plasmodium falciparum.,Bernstein NK, Cherney MM, Loetscher H, Ridley RG, James MN Nat Struct Biol. 1999 Jan;6(1):32-7. PMID:9886289<ref>PMID:9886289</ref>
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Authors: Recacha, R., Akopjana, I., Tars, K., Jaudzems, K.
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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Description: Structure of proplasmepsin II from Plasmodium falciparum, Space Group P43212
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<div class="pdbe-citations 5bwy" style="background-color:#fffaf0;"></div>
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[[Category: Unreleased Structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Akopjana, I]]
[[Category: Jaudzems, K]]
[[Category: Jaudzems, K]]
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[[Category: Recacha, R]]
[[Category: Tars, K]]
[[Category: Tars, K]]
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[[Category: Akopjana, I]]
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[[Category: Hydrolase]]
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[[Category: Recacha, R]]
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[[Category: Malaria]]

Revision as of 13:51, 16 December 2015

Structure of proplasmepsin II from Plasmodium falciparum, Space Group P43212

5bwy, resolution 2.64Å

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