5c5z
From Proteopedia
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| - | ''' | + | ==Crystal structure analysis of c4763, a uropathogenic E. coli-specific protein== |
| + | <StructureSection load='5c5z' size='340' side='right' caption='[[5c5z]], [[Resolution|resolution]] 1.45Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5c5z]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C5Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c5z OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5c5z RCSB], [http://www.ebi.ac.uk/pdbsum/5c5z PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Urinary-tract infections (UTIs), which are some of the most common infectious diseases in humans, can cause sepsis and death without proper treatment. Therefore, it is necessary to understand their pathogenicity for proper diagnosis and therapeutics. Uropathogenic Escherichia coli, the major causative agents of UTIs, contain several genes that are absent in nonpathogenic strains and are therefore considered to be relevant to UTI pathogenicity. c4763 is one of the uropathogenic E. coli-specific proteins, but its function is unknown. To investigate the function of c4763 and its possible role in UTI pathogenicity, its crystal structure was determined at a resolution of 1.45 A by a multiple-wavelength anomalous diffraction method. c4763 is a homodimer with 129 residues in one subunit that contains a GGCT-like domain with five alpha-helices and seven beta-strands. c4763 shows structural similarity to the C-terminal domain of allophanate hydrolase from Kluyveromyces lactis, which is involved in the degradation of urea. These results suggest that c4763 might be involved in the utilization of urea, which is necessary for bacterial survival in the urinary tract. Further biochemical and physiological investigation will elucidate its functional relevance in UTIs. | ||
| - | + | Crystal structure analysis of c4763, a uropathogenic Escherichia coli-specific protein.,Kim H, Choi J, Kim D, Kim KK Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):1042-7. doi:, 10.1107/S2053230X15013035. Epub 2015 Jul 29. PMID:26249697<ref>PMID:26249697</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | == References == | |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Choi, J]] | [[Category: Choi, J]] | ||
| + | [[Category: Kim, D]] | ||
[[Category: Kim, H]] | [[Category: Kim, H]] | ||
| - | [[Category: Kim, K | + | [[Category: Kim, K K]] |
| - | [[Category: | + | [[Category: Ggct-like domain]] |
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Urea]] | ||
| + | [[Category: Uropathogenic e. coli]] | ||
Revision as of 12:19, 20 August 2015
Crystal structure analysis of c4763, a uropathogenic E. coli-specific protein
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Categories: Choi, J | Kim, D | Kim, H | Kim, K K | Ggct-like domain | Hydrolase | Urea | Uropathogenic e. coli
