4mt2
From Proteopedia
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|PDB= 4mt2 |SIZE=350|CAPTION= <scene name='initialview01'>4mt2</scene>, resolution 2.0Å | |PDB= 4mt2 |SIZE=350|CAPTION= <scene name='initialview01'>4mt2</scene>, resolution 2.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4mt2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4mt2 OCA], [http://www.ebi.ac.uk/pdbsum/4mt2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=4mt2 RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Robbins, A H.]] | [[Category: Robbins, A H.]] | ||
[[Category: Stout, C D.]] | [[Category: Stout, C D.]] | ||
| - | [[Category: ACE]] | ||
| - | [[Category: CD]] | ||
| - | [[Category: NA]] | ||
| - | [[Category: ZN]] | ||
[[Category: metallothionein]] | [[Category: metallothionein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:39:30 2008'' |
Revision as of 02:39, 31 March 2008
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| , resolution 2.0Å | |||||||
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| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
COMPARISON OF THE NMR SOLUTION STRUCTURE AND THE X-RAY CRYSTAL STRUCTURE OF RAT METALLOTHIONEIN-2
Overview
Metallothioneins are small cysteine-rich proteins capable of binding heavy metal ions such as Zn2+ and Cd2+. They are ubiquitous tissue components in higher organisms, which tentatively have been attributed both unspecific protective functions against toxic metal ions and highly specific roles in fundamental zinc-regulated cellular processes. In this paper a detailed comparison of the NMR solution structure [Schultze, P., Worgotter, E., Braun, W., Wagner, G., Vasak, M., Kagi, J. H. R. & Wuthrich, K. (1988) J. Mol. Biol. 203, 251-268] and a recent x-ray crystal structure [Robbins, A. H., McRee, D. E., Williamson, M., Collett, S. A., Xoung, N. H., Furey, W. F., Wang, B. C. & Stout, C. D. (1991) J. Mol. Biol. 221, 1269-1293] of rat metallothionein-2 shows that the metallothionein structures in crystals and in solution have identical molecular architectures. The structures obtained with both techniques now present a reliable basis for discussions on structure-function correlations in this class of metalloproteins.
About this Structure
4MT2 is a Single protein structure of sequence from Rattus rattus. Full crystallographic information is available from OCA.
Reference
Comparison of the NMR solution structure and the x-ray crystal structure of rat metallothionein-2., Braun W, Vasak M, Robbins AH, Stout CD, Wagner G, Kagi JH, Wuthrich K, Proc Natl Acad Sci U S A. 1992 Nov 1;89(21):10124-8. PMID:1438200
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