Alpha-tubulin N-acetyltransferase
From Proteopedia
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(New page: <StructureSection load='3vwe' size='340' side='right' caption='Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code 3vwe)' scene=''> '''Alpha-tubulin N-ace...) |
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<StructureSection load='3vwe' size='340' side='right' caption='Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code [[3vwe]])' scene=''> | <StructureSection load='3vwe' size='340' side='right' caption='Human α-tubulin N-acetyltransferase catalytic domain complex with CoA (PDB code [[3vwe]])' scene=''> | ||
'''Alpha-tubulin N-acetyltransferase''' (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin. | '''Alpha-tubulin N-acetyltransferase''' (TAT) catalyzes the conversion of acetyl-CoA and tubulin-L-lysine to CoA and tubulin-N-acetyl-L-lysine. TAT acetylates Lys40 in tubulin and is required for normal sperm flagellar function. This posttranslational modification of tubulin is conserved in long-lived microtubules. TAT can acetylate itself and this acts as a regulatory mechanism for its action on tubulin. | ||
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| - | == Relevance == | ||
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| - | == Structural highlights == | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:45, 29 October 2015
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3D Structures of Alpha-tubulin N-acetyltransferase
Updated on 29-October-2015
4gs4, 4b5o, 4if5 – hTAT catalytic domain - human
4b5p – hTAT catalytic domain (mutant)
4h6z, 4yrh – zfTAT catalytic domain – zebra fish
4h6u – zfTAT catalytic domain (mutant)
4hkf – zfTAT catalytic domain + acetyl-CoA
3vwd – hTAT catalytic domain + acetoacetyl-CoA
3vwe – hTAT catalytic domain + CoA
4pk2, 4pk3 – hTAT catalytic domain + bisubstrate analog
