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5c91

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'''Unreleased structure'''
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==NEDD4 HECT with covalently bound indole-based inhibitor==
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<StructureSection load='5c91' size='340' side='right' caption='[[5c91]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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The entry 5c91 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5c91]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C91 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C91 FirstGlance]. <br>
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Authors: Span, I., Smith, A.T., Kathman, S., Statsyuk, A.V., Rosenzweig, A.C.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4YU:METHYL+(2E)-4-{[(5-METHOXY-1,2-DIMETHYL-1H-INDOL-3-YL)CARBONYL]AMINO}BUT-2-ENOATE'>4YU</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xbf|2xbf]], [[2xbb|2xbb]]</td></tr>
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Description:
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c91 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c91 OCA], [http://pdbe.org/5c91 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c91 RCSB], [http://www.ebi.ac.uk/pdbsum/5c91 PDBsum]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Statsyuk, A.V]]
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== Function ==
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[[Category: Span, I]]
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[[http://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN]] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>
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[[Category: Rosenzweig, A.C]]
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== References ==
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[[Category: Smith, A.T]]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Kathman, S]]
[[Category: Kathman, S]]
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[[Category: Rosenzweig, A C]]
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[[Category: Smith, A T]]
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[[Category: Span, I]]
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[[Category: Statsyuk, A V]]
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[[Category: Hect]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Nedd4]]

Revision as of 14:43, 30 September 2015

NEDD4 HECT with covalently bound indole-based inhibitor

5c91, resolution 2.44Å

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