TNF receptor-associated factor

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<StructureSection load='1f3v' size='340' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein (grey) (PDB code [[1d01]])' scene=''>
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<StructureSection load='1f3v' size='340' side='right' caption='Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (grey) (PDB code [[1d01]])' scene=''>
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF2-6 have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK.
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== Function ==
== Function ==
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'''TNF receptor-associated factor''' (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins<ref>PMID:11607847</ref>. '''TRAF2-6''' have N-terminal RING and zinc finger motifs. '''TRAF2, TRAF5 and TRAF6''' mediate activation of NF-κB and JNK.
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== Disease ==
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== Relevance ==
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== Structural highlights ==
== Structural highlights ==
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The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions<ref>PMID:10892748</ref>.
</StructureSection>
</StructureSection>
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*TRAF2
*TRAF2
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**[[1ca4]] – hTRAF2 TRAF domain <br />
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**[[1ca4]] – hTRAF2 TRAF domain residues 334-501<br />
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**[[3knv]] – hTRAF2 RING+zinc finger 1 domains <br />
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**[[3knv]] – hTRAF2 RING+zinc finger 1 domains residues 1-133 <br />
**[[3m06]] – hTRAF2 residues 266-329 <br />
**[[3m06]] – hTRAF2 residues 266-329 <br />

Revision as of 07:50, 15 September 2016

Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (grey) (PDB code 1d01)

Drag the structure with the mouse to rotate

3D Structures of TNF receptor-associated factor

Updated on 15-September-2016

References

  1. ↑ Bradley JR, Pober JS. Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene. 2001 Oct 1;20(44):6482-91. PMID:11607847 doi:http://dx.doi.org/10.1038/sj.onc.1204788
  2. ↑ Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H. A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 2000 Jun 23;101(7):777-87. PMID:10892748

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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