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Baculoviral IAP repeat-containing protein
From Proteopedia
(Difference between revisions)
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<StructureSection load='3d9t' size='340' side='right' caption='Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (grey and green) complex with caspase-9 peptide (pink and yellow) and Zn+2 ions (PDB code [[3d9t]]) ' scene=''> | <StructureSection load='3d9t' size='340' side='right' caption='Human Baculoviral IAP repeat-containing protein 2 BIR3 domain (grey and green) complex with caspase-9 peptide (pink and yellow) and Zn+2 ions (PDB code [[3d9t]]) ' scene=''> | ||
| + | == Function == | ||
*'''Baculoviral IAP repeat-containing protein 1''' (BIRC1 or NAIP) inhibits the activities of caspase-3,7,9. BIRC1 acts as mediator of neuronal survival in pathological conditions and prevents motor-neuron apoptosis.<br /> | *'''Baculoviral IAP repeat-containing protein 1''' (BIRC1 or NAIP) inhibits the activities of caspase-3,7,9. BIRC1 acts as mediator of neuronal survival in pathological conditions and prevents motor-neuron apoptosis.<br /> | ||
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*'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br /> | *'''Baculoviral IAP repeat-containing protein 7''' or melanoma inhibitor of apoptosis (ML-IAP) contains one BIR and one RING domain. ML-IAP has 2 isoforms. Isoform-a protects cells from staurosporine-induced apoptosis and isoform-b protects cells from etoposide-induced apoptpsis.<br /> | ||
*'''Baculoviral IAP repeat-containing protein 8''' (BIRC8).<br /> | *'''Baculoviral IAP repeat-containing protein 8''' (BIRC8).<br /> | ||
| + | == Disease == | ||
cIAP1 is a target for intervention against type 2 diabetes. Mutated or deleted BIRC1 were found in individuals with severe muscular atrophy. | cIAP1 is a target for intervention against type 2 diabetes. Mutated or deleted BIRC1 were found in individuals with severe muscular atrophy. | ||
Revision as of 12:23, 8 November 2015
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3D Structures of Baculoviral IAP repeat-containing protein
Updated on 08-November-2015
