Hydroxysteroid dehydrogenase
From Proteopedia
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{{STRUCTURE_1lwi| PDB=1lwi | SIZE=400| SCENE= |right| CAPTION=Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]] }} | {{STRUCTURE_1lwi| PDB=1lwi | SIZE=400| SCENE= |right| CAPTION=Rat 3-α hydroxysteroid dehydrogenase dimer complex with cofactor NADP [[1lwi]] }} | ||
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| - | + | '''Hydroxysteroid dehydrogenase''' (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on.<br /> | |
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| - | '''Hydroxysteroid dehydrogenase''' (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of carbon it is acting on.<br /> | + | |
* '''3-α HSD''' catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.<br /> | * '''3-α HSD''' catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.<br /> | ||
* '''7-α HSD''' is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.<br /> | * '''7-α HSD''' is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.<br /> | ||
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* '''17-β HSD''' is involved in the conversion of androstenedione to testosterone.<br /> | * '''17-β HSD''' is involved in the conversion of androstenedione to testosterone.<br /> | ||
* '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.<br /> | * '''3-β/17-β HSD''' catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.<br /> | ||
| - | NAD and NADP are cofactors of HSD. | + | [[NAD]] and NADP are cofactors of HSD. |
==3D structures of hydroxysteroid dehydrogenase== | ==3D structures of hydroxysteroid dehydrogenase== | ||
Revision as of 09:02, 27 March 2016
Hydroxysteroid dehydrogenase (HSD) catalyzes the dehydrogenation of hydroxysteroids. HSD is classified according to the number of the carbon it is acting on.
- 3-α HSD catalyzes the conversion of androsterone to 5α-androstane-3, 17-dione and 17-α estradiol to estrone. 3-α HSD (also named 17-α HSD) is a bile acid-metabolizing enzyme.
- 7-α HSD is involved in the dehydrogenation of cholanate compounds and is a bile acid-inducible enzyme.
- 20-α HSD is involved in the control of progesterone level in pregnancy of mice.
- 11-β HSD converts 11-keto products like cortisone to cortisol.
- 17-β HSD is involved in the conversion of androstenedione to testosterone.
- 3-β/17-β HSD catalyzes the reversible dehydrogenation of steroid compounds at position 3 and 17.
NAD and NADP are cofactors of HSD.
3D structures of hydroxysteroid dehydrogenase
Updated on 27-March-2016
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 see Prostaglandin F synthase
