Core-binding factor
From Proteopedia
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<StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (grey and pink) complex with CBFβ heterodimerization domain (green and yellow) and DNA (PDB code [[1h9d]])' scene=''> | <StructureSection load='1h9d' size='340' side='right' caption='Human CBFα runt domain (grey and pink) complex with CBFβ heterodimerization domain (green and yellow) and DNA (PDB code [[1h9d]])' scene=''> | ||
| - | '''Core-binding factor''' (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. CBF α contains a DNA-binding runt domain (residues 50-177). | ||
== Function == | == Function == | ||
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| + | '''Core-binding factor''' (CBF) is a heterodimeric transcription factor which is composed of α chain which binds DNA and a regulatory β chain. CBF binds to various enhancers and promoters including murine leukemia virus and polyomavirus enhancer. <ref>PMID:11276260</ref> | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
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| + | CBF α contains a DNA-binding runt domain (residues 50-177). | ||
</StructureSection> | </StructureSection> | ||
Revision as of 11:15, 14 December 2015
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3D Structures of core-binding factor
Updated on 14-December-2015
References
- ↑ Bravo J, Li Z, Speck NA, Warren AJ. The leukemia-associated AML1 (Runx1)--CBF beta complex functions as a DNA-induced molecular clamp. Nat Struct Biol. 2001 Apr;8(4):371-8. PMID:11276260 doi:http://dx.doi.org/10.1038/86264
