DXP reductoisomerase

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Revision as of 10:21, 11 January 2016

DXP reductoisomerase complex with NADPH, Mn+2 ion and anti-malaria drug fosmidomycin (PDB code 3zhy)

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Updated on 11-January-2016

↑ Takahashi S, Kuzuyama T, Watanabe H, Seto H. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9879-84. PMID:9707569

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 <StructureSection load='3zhy' size='340' side='right' caption='DXP reductoisomerase complex with NADPH, Mn+2 ion and  anti-malaria drug fosmidomycin (PDB code [[3zhy]])' scene=''>
-'''DXP reductoisomerase''' (DXR) or '''1-deoxy-D-xylulose-5-phosphate reductoisomerase''' or '''IspC''' catalyzes the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate.  DXR is part of the nonmevalonate pathway which synthesizes isoprenoids which are essential components of bacterial cell wall.  NADPH is a cofactor of the reaction.  Divalent metal cations (Mg+2, Mn+2) are involved in binding of the DXP substrate to DXR.
+'''DXP reductoisomerase''' (DXR) or '''1-deoxy-D-xylulose-5-phosphate reductoisomerase''' or '''IspC''' catalyzes the conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate.  DXR is part of the nonmevalonate pathway which synthesizes isoprenoids which are essential components of bacterial cell wall.  NADPH is a cofactor of the reaction.  Divalent metal cations (Mg+2, Mn+2) are involved in binding of the DXP substrate to DXR.<ref>PMID:9707569</ref>
 == Function ==