4xt9

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'''Unreleased structure'''
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==RORgamma (263-509) complexed with GSK2435341A and SRC2==
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<StructureSection load='4xt9' size='340' side='right' caption='[[4xt9]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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The entry 4xt9 is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4xt9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XT9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XT9 FirstGlance]. <br>
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Authors: Wang, Y., Ma, Y.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=43V:N-[4-(2,5-DICHLOROPHENYL)-5-PHENYL-1,3-THIAZOL-2-YL]-2-[4-(ETHYLSULFONYL)PHENYL]ACETAMIDE'>43V</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xt9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xt9 RCSB], [http://www.ebi.ac.uk/pdbsum/4xt9 PDBsum]</span></td></tr>
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Description: RORgamma (263-509) complexed with GSK2435341A and SRC2
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Wang, Y]]
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Ma, Y]]
[[Category: Ma, Y]]
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[[Category: Wang, Y]]
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[[Category: Unknown protein]]

Revision as of 14:49, 12 August 2015

RORgamma (263-509) complexed with GSK2435341A and SRC2

4xt9, resolution 2.25Å

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