5c7k
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195== |
| - | + | <StructureSection load='5c7k' size='340' side='right' caption='[[5c7k]], [[Resolution|resolution]] 4.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5c7k]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5C7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5C7K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5c7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5c7k OCA], [http://pdbe.org/5c7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5c7k RCSB], [http://www.ebi.ac.uk/pdbsum/5c7k PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/Q2N0S6_9HIV1 Q2N0S6_9HIV1]] The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface (By similarity).[RuleBase:RU004292][SAAS:SAAS000328_004_020447] The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves (By similarity).[SAAS:SAAS000328_004_240990] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Kong, L]] | [[Category: Kong, L]] | ||
| - | [[Category: Stanfield, R | + | [[Category: Stanfield, R L]] |
| - | [[Category: Wilson, I | + | [[Category: Wilson, I A]] |
| + | [[Category: Hiv-1]] | ||
| + | [[Category: Immune system]] | ||
| + | [[Category: Pgt128]] | ||
| + | [[Category: Sosip]] | ||
Revision as of 13:52, 7 October 2015
Crystal structure BG505 SOSIP gp140 HIV-1 Env trimer bound to broadly neutralizing antibodies PGT128 and 8ANC195
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Categories: Kong, L | Stanfield, R L | Wilson, I A | Hiv-1 | Immune system | Pgt128 | Sosip
