6pfk
From Proteopedia
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|PDB= 6pfk |SIZE=350|CAPTION= <scene name='initialview01'>6pfk</scene>, resolution 2.6Å | |PDB= 6pfk |SIZE=350|CAPTION= <scene name='initialview01'>6pfk</scene>, resolution 2.6Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC ACID'>PGA</scene> | + | |LIGAND= <scene name='pdbligand=PGA:2-PHOSPHOGLYCOLIC+ACID'>PGA</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span> |
|GENE= PFK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | |GENE= PFK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1422 Geobacillus stearothermophilus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6pfk OCA], [http://www.ebi.ac.uk/pdbsum/6pfk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=6pfk RCSB]</span> | ||
}} | }} | ||
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[[Category: Evans, P R.]] | [[Category: Evans, P R.]] | ||
[[Category: Schirmer, T.]] | [[Category: Schirmer, T.]] | ||
| - | [[Category: PGA]] | ||
[[Category: glycolysis]] | [[Category: glycolysis]] | ||
[[Category: kinase]] | [[Category: kinase]] | ||
[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:43:27 2008'' |
Revision as of 02:43, 31 March 2008
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| , resolution 2.6Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | PFK (Geobacillus stearothermophilus) | ||||||
| Activity: | 6-phosphofructokinase, with EC number 2.7.1.11 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
PHOSPHOFRUCTOKINASE, INHIBITED T-STATE
Overview
Comparison between the crystal structures of low- and high-affinity forms of phosphofructokinase shows a close coupling between the change of quaternary structure and local changes triggered by binding of the allosteric effectors. These concerted changes link all the substrate and effector sites in the tetramer, and explain the change of affinity for the cooperative substrate.
About this Structure
6PFK is a Single protein structure of sequence from Geobacillus stearothermophilus. This structure supersedes the now removed PDB entry 5PFK. The following page contains interesting information on the relation of 6PFK with [The Glycolytic Enzymes]. Full crystallographic information is available from OCA.
Reference
Structural basis of the allosteric behaviour of phosphofructokinase., Schirmer T, Evans PR, Nature. 1990 Jan 11;343(6254):140-5. PMID:2136935
Page seeded by OCA on Mon Mar 31 05:43:27 2008
