5cui
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Human Defensin-5 R28A mutant.== | |
| - | + | <StructureSection load='5cui' size='340' side='right' caption='[[5cui]], [[Resolution|resolution]] 2.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cui]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CUI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CUI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PG0:2-(2-METHOXYETHOXY)ETHANOL'>PG0</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1zmp|1zmp]], [[5cuj|5cuj]], [[5cum|5cum]]</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cui FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cui OCA], [http://pdbe.org/5cui PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cui RCSB], [http://www.ebi.ac.uk/pdbsum/5cui PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cui ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEF5_HUMAN DEF5_HUMAN]] Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing.<ref>PMID:12021776</ref> <ref>PMID:15616305</ref> <ref>PMID:17088326</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gohain, N]] | ||
[[Category: Pazgier, M]] | [[Category: Pazgier, M]] | ||
| - | [[Category: Tolbert, W | + | [[Category: Tolbert, W D]] |
| - | [[Category: | + | [[Category: Antimicrobial protein]] |
| + | [[Category: Human alpha-defensin]] | ||
| + | [[Category: Intestinal defensin]] | ||
| + | [[Category: Paneth cells defensin]] | ||
Revision as of 15:36, 27 July 2016
Crystal structure of Human Defensin-5 R28A mutant.
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