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2n5z
From Proteopedia
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| - | ''' | + | ==Mycobacterium tuberculosis: a dynamic view of the resuscitation promoting factor RpfC catalytic domain== |
| - | + | <StructureSection load='2n5z' size='340' side='right' caption='[[2n5z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[2n5z]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N5Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N5Z FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n5z OCA], [http://pdbe.org/2n5z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n5z RCSB], [http://www.ebi.ac.uk/pdbsum/2n5z PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | [[Category: | + | [[http://www.uniprot.org/uniprot/RPFC_MYCTU RPFC_MYCTU]] Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity.<ref>PMID:12410821</ref> Stimulates growth of stationary phase M.bovis (a slow-growing Mycobacterium), reduces the lag phase of diluted fast-growers M.smegmatis and Micrococcus luteus. Sequential gene disruption indicates RpfB and RpfE are higher than RpfD and RpfC in functional hierarchy.<ref>PMID:12410821</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Isernia, C]] | ||
[[Category: Maione, V]] | [[Category: Maione, V]] | ||
[[Category: Russo, L]] | [[Category: Russo, L]] | ||
| - | [[Category: | + | [[Category: Hydrolase]] |
| + | [[Category: Resuscitation promoting factor]] | ||
| + | [[Category: Rpfc]] | ||
Revision as of 04:40, 1 December 2015
Mycobacterium tuberculosis: a dynamic view of the resuscitation promoting factor RpfC catalytic domain
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