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4r9w
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of platelet factor 4 complexed with fondaparinux== |
| - | + | <StructureSection load='4r9w' size='340' side='right' caption='[[4r9w]], [[Resolution|resolution]] 2.50Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4r9w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R9W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R9W FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NTO:TRISULFOAMINO+HEPARIN+PENTASACCHARIDE'>NTO</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4r97|4r97]], [[4r9y|4r9y]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r9w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r9w OCA], [http://pdbe.org/4r9w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4r9w RCSB], [http://www.ebi.ac.uk/pdbsum/4r9w PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| - | [[ | + | == Function == |
| - | [[ | + | [[http://www.uniprot.org/uniprot/PLF4_HUMAN PLF4_HUMAN]] Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.<ref>PMID:7644496</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Cai, Z]] | [[Category: Cai, Z]] | ||
| + | [[Category: Greene, M I]] | ||
| + | [[Category: Liu, Q]] | ||
[[Category: Zhu, Z]] | [[Category: Zhu, Z]] | ||
| + | [[Category: Cxc chemokine]] | ||
| + | [[Category: Cytokine]] | ||
| + | [[Category: Fondaparinux]] | ||
| + | [[Category: Glycosaminoglycan]] | ||
| + | [[Category: Pf4]] | ||
| + | [[Category: Platelet]] | ||
| + | [[Category: Platelet factor]] | ||
Revision as of 13:53, 16 December 2015
Crystal structure of platelet factor 4 complexed with fondaparinux
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Categories: Cai, Z | Greene, M I | Liu, Q | Zhu, Z | Cxc chemokine | Cytokine | Fondaparinux | Glycosaminoglycan | Pf4 | Platelet | Platelet factor
