5cx3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of FYCO1 LIR in complex with LC3A== | |
| - | + | <StructureSection load='5cx3' size='340' side='right' caption='[[5cx3]], [[Resolution|resolution]] 2.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cx3]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CX3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cx3 OCA], [http://pdbe.org/5cx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cx3 RCSB], [http://www.ebi.ac.uk/pdbsum/5cx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cx3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] Nuclear cataract. The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).<ref>PMID:21636066</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MLP3A_HUMAN MLP3A_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] May mediate microtubule plus end-directed vesicle transport.<ref>PMID:20100911</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Lifeng, P]] | ||
[[Category: Xiaofang, C]] | [[Category: Xiaofang, C]] | ||
| - | [[Category: | + | [[Category: Autophagy adaptor]] |
| + | [[Category: Protein binding]] | ||
Revision as of 04:12, 4 August 2016
Crystal structure of FYCO1 LIR in complex with LC3A
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