5czu
From Proteopedia
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| - | ''' | + | ==Crystal structure of FeCat-Fn== |
| + | <StructureSection load='5czu' size='340' side='right' caption='[[5czu]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5czu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CZU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CZU FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4LF:N-[2-[2,5-BIS(OXIDANYLIDENE)PYRROL-1-YL]ETHYL]-2,3-BIS(OXIDANYL)BENZAMIDE'>4LF</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5axs|5axs]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5czu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5czu OCA], [http://pdbe.org/5czu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5czu RCSB], [http://www.ebi.ac.uk/pdbsum/5czu PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FRIL_HORSE FRIL_HORSE]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A set of three catecholamide ligands mimicking the structure of enterobactin was constructed on ferritin, where the 3-fold symmetric arrangement of the monomer subunits served as a foundation to form a coordination space. Similar to enterobactin, the ligands showed strong affinity for the ferric ion and formed a tris-catechoyl complex. Crystallography revealed that the complex was embedded in the entrance of the 3-fold axis channel. | ||
| - | + | Construction of an enterobactin analogue with symmetrically arranged monomer subunits of ferritin.,Nakajima H, Kondo M, Nakane T, Abe S, Nakao T, Watanabe Y, Ueno T Chem Commun (Camb). 2015 Dec 4;51(93):16609-12. doi: 10.1039/c5cc06904a. Epub, 2015 Sep 25. PMID:26404005<ref>PMID:26404005</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| - | + | <div class="pdbe-citations 5czu" style="background-color:#fffaf0;"></div> | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Abe, S]] | ||
| + | [[Category: Kondo, M]] | ||
| + | [[Category: Nakajima, H]] | ||
| + | [[Category: Nakane, T]] | ||
[[Category: Nakao, T]] | [[Category: Nakao, T]] | ||
| - | [[Category: Abe, S]] | ||
[[Category: Ueno, T]] | [[Category: Ueno, T]] | ||
[[Category: Watanabe, Y]] | [[Category: Watanabe, Y]] | ||
| - | [[Category: | + | [[Category: Iron storage]] |
| - | [[Category: | + | [[Category: Metal binding protein]] |
| - | + | ||
Revision as of 18:19, 30 November 2015
Crystal structure of FeCat-Fn
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Categories: Abe, S | Kondo, M | Nakajima, H | Nakane, T | Nakao, T | Ueno, T | Watanabe, Y | Iron storage | Metal binding protein
