4zgz

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'''Unreleased structure'''
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==STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME==
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<StructureSection load='4zgz' size='340' side='right' caption='[[4zgz]], [[Resolution|resolution]] 5.81&Aring;' scene=''>
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The entry 4zgz is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4zgz]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZGZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZGZ FirstGlance]. <br>
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Authors: Chen, S.F., Wu, H.Y., Chan, N.L.
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4qcg|4qcg]], [[3btn|3btn]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zgz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zgz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4zgz RCSB], [http://www.ebi.ac.uk/pdbsum/4zgz PDBsum]</span></td></tr>
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Description: STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Wu, H.Y]]
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[[http://www.uniprot.org/uniprot/AZIN1_HUMAN AZIN1_HUMAN]] Antizyme inhibitor protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake by counteracting the negative effect of antizyme OAZ1, OAZ2 and OAZ3 on ODC1 activity (PubMed:17900240). Inhibits antizyme-dependent ODC degradation by binding to antizymes. Releases ODC1 from its inactive complex with antizymes, leading to formation of the catalytically active ODC1.<ref>PMID:17900240</ref> [[http://www.uniprot.org/uniprot/OAZ1_HUMAN OAZ1_HUMAN]] Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake by binding to and targeting ODC1 for degradation (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.<ref>PMID:12097147</ref> <ref>PMID:17900240</ref>
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[[Category: Chan, N.L]]
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== References ==
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[[Category: Chen, S.F]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chan, N L]]
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[[Category: Chen, S F]]
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[[Category: Wu, H Y]]
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[[Category: Antizyme]]
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[[Category: Beta-sheet domain]]
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[[Category: Inhibition]]
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[[Category: Plasma]]
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[[Category: Protein binding]]
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[[Category: Tim barrel domain]]

Revision as of 12:31, 2 September 2015

STRUCTURE OF HUMAN ANTIZYME INHIBITOR IN COMPLEX WITH A C-TERMINAL FRAGMENT OF ANTIZYME

4zgz, resolution 5.81Å

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