5d7o

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'''Unreleased structure'''
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==Crystal structure of Sirt2-ADPR at an improved resolution==
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<StructureSection load='5d7o' size='340' side='right' caption='[[5d7o]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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The entry 5d7o is ON HOLD until Paper Publication
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5d7o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7O FirstGlance]. <br>
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Authors: Rumpf, T., Gerhardt, S., Einsle, O., Jung, M.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7o OCA], [http://pdbe.org/5d7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7o RCSB], [http://www.ebi.ac.uk/pdbsum/5d7o PDBsum]</span></td></tr>
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Description:
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</table>
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[[Category: Unreleased Structures]]
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== Function ==
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[[Category: Rumpf, T]]
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[[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Einsle, O]]
[[Category: Gerhardt, S]]
[[Category: Gerhardt, S]]
[[Category: Jung, M]]
[[Category: Jung, M]]
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[[Category: Einsle, O]]
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[[Category: Rumpf, T]]
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[[Category: Deacylase]]
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[[Category: Human sirt2]]
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[[Category: Hydrolase]]

Revision as of 16:17, 2 December 2015

Crystal structure of Sirt2-ADPR at an improved resolution

5d7o, resolution 1.63Å

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