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Nicotinic Acetylcholine Receptor
From Proteopedia
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This protein carries anywhere from 2 to 5 [[acetylcholine]] binding sites which are located at the interface between two subunits. Each subunit contributes 3 loops to the binding site. There is also a "principle" side and a "complimentary" side of the subunits. The principle side binding nicotine with a high degree of specificity and the complimentary side binding a wide variety of acetylcholine like molecules. | This protein carries anywhere from 2 to 5 [[acetylcholine]] binding sites which are located at the interface between two subunits. Each subunit contributes 3 loops to the binding site. There is also a "principle" side and a "complimentary" side of the subunits. The principle side binding nicotine with a high degree of specificity and the complimentary side binding a wide variety of acetylcholine like molecules. | ||
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| + | See also [[Binding site of AChR]]. | ||
=== Ion Channel === | === Ion Channel === | ||
Revision as of 17:29, 4 January 2016
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3D Structures of nicotinic acetylcholine receptor
Updated on 04-January-2016
4d01 – hAChR α-9 subunit extracellular domain – human
4uxu – hAChR α-9 subunit extracellular domain + methyllycaconitine
4uy2 – hAChR α-9 subunit extracellular domain + α-bungarotoxin
2qc1 – AChR α subunit extracellular domain + α-bungarotoxin - mouse
3mra – TcAChR α subunit M3 transmembrane segment – Torpedo californica - NMR
2k58 – AChR beta-2 subunit M1 transmembrane segment - NMR
2k59 – AChR beta-2 subunit M2 transmembrane segment - NMR
1oed – TmAChR pore – Torpedo marmorata – electron images
2bg9, 4aq5, 4aq9, 4bog, 4boi, 4bon, 4boo, 4bor, 4bot – TmAChR – Cryo-EM
References
1. Cholinesterase Inhibitors: Including Insecticides and Chemical Warfare Nerve Agents, Agency for Toxiz Substances and Disease Regulation accessed 5/2/14
2. Pierre-Jean Corringer and Jean-Pierre Changeux (2008) Nicotinic acetylcholine receptors. Scholarpedia, 3(1):3468.
3. Adcock C, Smith GR, Sansom MS. The nicotinic acetylcholine receptor: from molecular model to single-channel conductance. Eur Biophys J. 2000;29:29–37.
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