5d94
From Proteopedia
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| - | ''' | + | ==Crystal structure of LC3-LIR peptide complex== |
| - | + | <StructureSection load='5d94' size='340' side='right' caption='[[5d94]], [[Resolution|resolution]] 1.53Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5d94]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D94 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d94 OCA], [http://pdbe.org/5d94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d94 RCSB], [http://www.ebi.ac.uk/pdbsum/5d94 PDBsum]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Disease == | |
| - | [[ | + | [[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] Nuclear cataract. The disease is caused by mutations affecting the gene represented in this entry. Pathogenic mutations in FYCO1 can affect intracellular transport of autophagocytic vesicles from the perinuclear area to the periphery, leading to an accumulation of large numbers of vesicles and hence loss of lens transparency (PubMed:21636066).<ref>PMID:21636066</ref> |
| - | [[ | + | == Function == |
| + | [[http://www.uniprot.org/uniprot/MLP3B_HUMAN MLP3B_HUMAN]] Involved in formation of autophagosomal vacuoles (autophagosomes). [[http://www.uniprot.org/uniprot/FYCO1_HUMAN FYCO1_HUMAN]] May mediate microtubule plus end-directed vesicle transport.<ref>PMID:20100911</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Johansen, T]] | [[Category: Johansen, T]] | ||
[[Category: Mizushima, T]] | [[Category: Mizushima, T]] | ||
| + | [[Category: Takagi, K]] | ||
| + | [[Category: Autophagy]] | ||
| + | [[Category: Fyco1]] | ||
| + | [[Category: Lc3]] | ||
| + | [[Category: Lir]] | ||
| + | [[Category: Protein binding-peptide complex]] | ||
Revision as of 05:33, 22 October 2015
Crystal structure of LC3-LIR peptide complex
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