5dfz
From Proteopedia
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- | ''' | + | ==Structure of Vps34 complex II from S. cerevisiae.== |
- | + | <StructureSection load='5dfz' size='340' side='right' caption='[[5dfz]], [[Resolution|resolution]] 4.40Å' scene=''> | |
- | + | == Structural highlights == | |
- | + | <table><tr><td colspan='2'>[[5dfz]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DFZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DFZ FirstGlance]. <br> | |
- | + | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | |
- | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphatidylinositol_3-kinase Phosphatidylinositol 3-kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.137 2.7.1.137] </span></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dfz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dfz OCA], [http://pdbe.org/5dfz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dfz RCSB], [http://www.ebi.ac.uk/pdbsum/5dfz PDBsum]</span></td></tr> | |
- | [[ | + | </table> |
- | [[Category: | + | == Function == |
- | [[Category: | + | [[http://www.uniprot.org/uniprot/VPS38_YEAST VPS38_YEAST]] Involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through generating a specific pool of phosphatidylinositol 3-phosphate allowing the recruitment of the retromer complex proteins to the endosome). Mediates the interaction between VPS30 and the VPS34-VPS15 core complex, leading to the recruitment of VPS30 to the membrane.<ref>PMID:11157979</ref> <ref>PMID:12244127</ref> <ref>PMID:9265642</ref> [[http://www.uniprot.org/uniprot/VPS15_YEAST VPS15_YEAST]] Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Is also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). By regulating VPS34 kinase activity, VPS15 appears to be essential for the efficient delivery of soluble hydrolases to the yeast vacuole.<ref>PMID:1988155</ref> <ref>PMID:3062374</ref> <ref>PMID:1756716</ref> <ref>PMID:8387919</ref> <ref>PMID:8509446</ref> <ref>PMID:7989323</ref> <ref>PMID:8649377</ref> <ref>PMID:11157979</ref> <ref>PMID:12244127</ref> [[http://www.uniprot.org/uniprot/VPS34_YEAST VPS34_YEAST]] Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Its activation by VPS15 may lead to the phosphorylation of phosphatidylinositol in the sorting compartment membrane. Finally, it might also be involved in ethanol tolerance and cell wall integrity.<ref>PMID:11157979</ref> <ref>PMID:11523784</ref> <ref>PMID:12244127</ref> <ref>PMID:2247081</ref> <ref>PMID:2555343</ref> <ref>PMID:3062374</ref> <ref>PMID:7929582</ref> <ref>PMID:7989323</ref> <ref>PMID:8385367</ref> <ref>PMID:8387919</ref> [[http://www.uniprot.org/uniprot/BECN1_YEAST BECN1_YEAST]] Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II. This second complex is required for the endosome-to-Golgi retrieval of PEP1 and KEX2, and the recruitment of VPS5 and VPS7, two components of the retromer complex, to endosomal membranes (probably through the synthesis of a specific pool of phosphatidylinositol 3-phosphate recruiting the retromer to the endosomes). Plays also a role in regulation of filamentous growth.<ref>PMID:11157979</ref> <ref>PMID:11689437</ref> <ref>PMID:12244127</ref> <ref>PMID:16267277</ref> <ref>PMID:17404498</ref> <ref>PMID:17700056</ref> <ref>PMID:18182384</ref> <ref>PMID:18701704</ref> <ref>PMID:19131141</ref> <ref>PMID:22437838</ref> <ref>PMID:23878393</ref> <ref>PMID:8224160</ref> <ref>PMID:9105038</ref> <ref>PMID:9712845</ref> |
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Phosphatidylinositol 3-kinase]] | ||
+ | [[Category: Ohashi, Y]] | ||
[[Category: Rostislavleva, K]] | [[Category: Rostislavleva, K]] | ||
+ | [[Category: Soler, N]] | ||
+ | [[Category: Williams, R L]] | ||
[[Category: Zhang, L]] | [[Category: Zhang, L]] | ||
- | [[Category: | + | [[Category: Autophagy]] |
+ | [[Category: Bara]] | ||
+ | [[Category: C2]] | ||
+ | [[Category: Coiled-coil]] | ||
+ | [[Category: Complex ii]] | ||
+ | [[Category: Heat]] | ||
+ | [[Category: Kinase]] | ||
+ | [[Category: Lipid]] | ||
+ | [[Category: Nanobody]] | ||
+ | [[Category: Pi3p]] | ||
+ | [[Category: Transferase]] | ||
+ | [[Category: Vacuolar protein sorting]] | ||
+ | [[Category: Vps15]] | ||
+ | [[Category: Vps30]] | ||
+ | [[Category: Vps34]] | ||
+ | [[Category: Vps38]] | ||
+ | [[Category: Wd40]] | ||
+ | [[Category: Yeast]] |
Revision as of 13:53, 7 October 2015
Structure of Vps34 complex II from S. cerevisiae.
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Categories: Phosphatidylinositol 3-kinase | Ohashi, Y | Rostislavleva, K | Soler, N | Williams, R L | Zhang, L | Autophagy | Bara | C2 | Coiled-coil | Complex ii | Heat | Kinase | Lipid | Nanobody | Pi3p | Transferase | Vacuolar protein sorting | Vps15 | Vps30 | Vps34 | Vps38 | Wd40 | Yeast