Lipase

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== '''Introduction''' ==
== '''Introduction''' ==
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'''Lipase''' catalyzes the breakdown of lipids by hydrolyzing the esters of fatty acids. Its function is important for digestion and promoting absorption of fats in the intestines. Lipase is primarily found in and secreted by the pancreas, but is also found in the saliva and stomach. Pancreatic lipase (PDB ID: [[1hpl]]) which is pictured to the right, is a carboxylic ester hydrolase. It is also commonly called pancreatic triacylglycerol lipase and its enzyme class number is E.C. 3.1.1.3 <ref name="1HPL PDB SUM">[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1hpl&template=main.html] 1HPL PDB SUM </ref>. The bile salt-stimulated lipase (BSSL) is found in breast milk. The hormone-sensitive lipase (LIPE) hydrolyzes a variety of esters. Monoacylglycerol lipase (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol. MAGL functions together with LIPE. The reaction catalyzed by the enzyme is shown below.
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'''Lipase''' catalyzes the breakdown of lipids by hydrolyzing the esters of fatty acids. Its function is important for digestion and promoting absorption of fats in the intestines. Lipase is primarily found in and secreted by the pancreas, but is also found in the saliva and stomach.<br />
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* '''Pancreatic lipase''' (PDB ID: [[1hpl]]) which is pictured to the right, is a carboxylic ester hydrolase. It is also commonly called '''pancreatic triacylglycerol lipase''' and its enzyme class number is E.C. 3.1.1.3 <ref name="1HPL PDB SUM">[http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1hpl&template=main.html] 1HPL PDB SUM </ref>.<br />
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* The '''bile salt-stimulated lipase''' (BSSL) is found in breast milk.<br />
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* The '''hormone-sensitive lipase''' (LIPE) hydrolyzes a variety of esters.<br />
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* '''Monoacylglycerol lipase''' (MAGL) hydrolyzes intracellular triglycerides to fatty acid and glycerol. MAGL functions together with LIPE. The reaction catalyzed by the enzyme is shown below.
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For more details on eukaryotic lipase see [[Human gastric lipase]].
[[Image:Picture 1.png]]
[[Image:Picture 1.png]]

Revision as of 15:44, 13 January 2017

Structure of Pancreatic Lipase (PDB entry 1akn)

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3D Structures of Lipase

Updated on 13-January-2017

References

  1. [1] 1HPL PDB SUM
  2. [2] A cross-linked complex between horse pancreatic lipase and colipase
  3. [3] History of Lipids
  4. [4] 1HPL PDB
  5. http://www.pdb.org/pdb/explore/explore.do?structureId=1HPL
  6. http://www.pdb.org/pdb/explore/remediatedSequence.do?structureId=1HPL
  7. http://www.springerlink.com/content/g5h1613440115701/fulltext.pdf
  8. Fundamentals of Biochemistry...
  9. Thomas, A. etc. "Role of the Lid Hydrophobicity Pattern in Pancreatic Lipase Activity", The Journal of Biological Chemistry, 2005 September 22; 270 (48): 40074-40083.
  10. "Colipase". Wikipedia: The Free Encyclopedia. 5 July 2011 [5]
  11. "Colipase Residues..."
  12. Fundamentals of Biochemistry...
  13. Crandall,W., Lowe, M. "Colipase Residues Glu64 and Arg65 Are Essential for Normal Lipase-mediated Fat Digestion in the Presence of Bile Salt Micelles" Journal of Biological Chemistry, 2001, (276) 12505-12512
  14. van Tilbeurgh H, etc."Structure of the pancreatic lipase-procolipase complex", 1992 Sep 10;359(6391):159-62. PMID:1522902.[6]
  15. http://www.pdb.org/pdb/explore/explore.do?structureId=1ETH
  16. http://www.nature.com/nature/journal/v362/n6423/abs/362814a0.html
  17. Sussman JL, Harel M, Frolow F, Oefner C, Goldman A, Toker L, Silman I. Atomic structure of acetylcholinesterase from Torpedo californica: a prototypic acetylcholine-binding protein. Science. 1991 Aug 23;253(5022):872-9. PMID:1678899
  18. Ollis DL, Cheah E, Cygler M, Dijkstra B, Frolow F, Franken SM, Harel M, Remington SJ, Silman I, Schrag J, et al.. The alpha/beta hydrolase fold. Protein Eng. 1992 Apr;5(3):197-211. PMID:1409539
  19. Bourne Y, Martinez C, Kerfelec B, Lombardo D, Chapus C, Cambillau C. Horse pancreatic lipase. The crystal structure refined at 2.3 A resolution. J Mol Biol. 1994 May 20;238(5):709-32. PMID:8182745 doi:http://dx.doi.org/10.1006/jmbi.1994.1331
  20. [7] 1LPB PDB SUM
  21. "Pancreatic lipase". Wikipedia: The Free Encyclopedia. 7 Nov 2011 [8]
  22. Kordik, C., Reitz, A. "Pharmacological Treatment of Obesity: Therapeutic Strategies" Journal of Medicinal Chemistry, 1999 (42).
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