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5def
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==Crystal structure of B*27:04 complex bound to the pVIPR peptide== |
| - | + | <StructureSection load='5def' size='340' side='right' caption='[[5def]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5def]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEF FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1of2|1of2]], [[1ogt|1ogt]]</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5def FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5def OCA], [http://pdbe.org/5def PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5def RCSB], [http://www.ebi.ac.uk/pdbsum/5def PDBsum]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Fabian, H]] | [[Category: Fabian, H]] | ||
| - | [[Category: Hee, C | + | [[Category: Hee, C S]] |
| - | [[Category: | + | [[Category: Huser, H]] |
[[Category: Loll, B]] | [[Category: Loll, B]] | ||
| + | [[Category: Uchanska-Ziegler, B]] | ||
[[Category: Ziegler, A]] | [[Category: Ziegler, A]] | ||
| - | [[Category: | + | [[Category: Hla- b*2704]] |
| + | [[Category: Immune system]] | ||
| + | [[Category: Immune system-complex]] | ||
Revision as of 19:00, 1 December 2015
Crystal structure of B*27:04 complex bound to the pVIPR peptide
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