1js3
From Proteopedia
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|PDB= 1js3 |SIZE=350|CAPTION= <scene name='initialview01'>1js3</scene>, resolution 2.25Å | |PDB= 1js3 |SIZE=350|CAPTION= <scene name='initialview01'>1js3</scene>, resolution 2.25Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=142:CARBIDOPA'>142</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5'-PHOSPHATE'>PLP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aromatic-L-amino-acid_decarboxylase Aromatic-L-amino-acid decarboxylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.1.28 4.1.1.28] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1js6|1JS6]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1js3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1js3 OCA], [http://www.ebi.ac.uk/pdbsum/1js3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1js3 RCSB]</span> | ||
}} | }} | ||
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[[Category: Jansonius, J N.]] | [[Category: Jansonius, J N.]] | ||
[[Category: Malashkevich, V N.]] | [[Category: Malashkevich, V N.]] | ||
| - | [[Category: 142]] | ||
| - | [[Category: PLP]] | ||
| - | [[Category: SO4]] | ||
[[Category: carbidopa]] | [[Category: carbidopa]] | ||
[[Category: dopa decarboxylase]] | [[Category: dopa decarboxylase]] | ||
| Line 36: | Line 36: | ||
[[Category: vitamin b6]] | [[Category: vitamin b6]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 21:38:11 2008'' |
Revision as of 18:38, 30 March 2008
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| , resolution 2.25Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Activity: | Aromatic-L-amino-acid decarboxylase, with EC number 4.1.1.28 | ||||||
| Related: | 1JS6
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of dopa decarboxylase in complex with the inhibitor carbidopa
Overview
DOPA decarboxylase (DDC) is responsible for the synthesis of the key neurotransmitters dopamine and serotonin via decarboxylation of L-3,4-dihydroxyphenylalanine (L-DOPA) and L-5-hydroxytryptophan, respectively. DDC has been implicated in a number of clinic disorders, including Parkinson's disease and hypertension. Peripheral inhibitors of DDC are currently used to treat these diseases. We present the crystal structures of ligand-free DDC and its complex with the anti-Parkinson drug carbiDOPA. The inhibitor is bound to the enzyme by forming a hydrazone linkage with the cofactor, and its catechol ring is deeply buried in the active site cleft. The structures provide the molecular basis for the development of new inhibitors of DDC with better pharmacological characteristics.
About this Structure
1JS3 is a Single protein structure of sequence from Sus scrofa. Full crystallographic information is available from OCA.
Reference
Structural insight into Parkinson's disease treatment from drug-inhibited DOPA decarboxylase., Burkhard P, Dominici P, Borri-Voltattorni C, Jansonius JN, Malashkevich VN, Nat Struct Biol. 2001 Nov;8(11):963-7. PMID:11685243
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