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1qf4
From Proteopedia
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|PDB= 1qf4 |SIZE=350|CAPTION= <scene name='initialview01'>1qf4</scene>, resolution 2.2Å | |PDB= 1qf4 |SIZE=350|CAPTION= <scene name='initialview01'>1qf4</scene>, resolution 2.2Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5'-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=RPD:(C8-R)-HYDANTOCIDIN+5'-PHOSPHATE'>RPD</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenylosuccinate_synthase Adenylosuccinate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.4.4 6.3.4.4] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qf4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qf4 OCA], [http://www.ebi.ac.uk/pdbsum/1qf4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1qf4 RCSB]</span> | ||
}} | }} | ||
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[[Category: Prade, L.]] | [[Category: Prade, L.]] | ||
[[Category: Sanceau, J Y.]] | [[Category: Sanceau, J Y.]] | ||
| - | [[Category: GDP]] | ||
| - | [[Category: MG]] | ||
| - | [[Category: PO4]] | ||
| - | [[Category: RPD]] | ||
[[Category: gtp-binding]] | [[Category: gtp-binding]] | ||
[[Category: gtp-hydrolysing enzyme]] | [[Category: gtp-hydrolysing enzyme]] | ||
| Line 40: | Line 39: | ||
[[Category: synthetase]] | [[Category: synthetase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:12:36 2008'' |
Revision as of 20:12, 30 March 2008
| |||||||
| , resolution 2.2Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Activity: | Adenylosuccinate synthase, with EC number 6.3.4.4 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
DESIGN, SYNTHESIS, AND X-RAY CRYSTAL STRUCTURE OF AN ENZYME BOUND BISUBSTRATE HYBRID INHIBITOR OF ADENYLOSUCCINATE SYNTHETASE
Overview
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C(3) chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate-enzyme complexes were determined.
About this Structure
1QF4 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
An Enzyme-Bound Bisubstrate Hybrid Inhibitor of Adenylosuccinate Synthetase., Hanessian S, Lu PP, Sanceau JY, Chemla P, Gohda K, Fonne-Pfister R, Prade L, Cowan-Jacob SW, Angew Chem Int Ed Engl. 1999 Nov 2;38(21):3159-3162. PMID:10556888
Page seeded by OCA on Sun Mar 30 23:12:36 2008
