1tm6

From Proteopedia

(Difference between revisions)

Revision as of 08:43, 21 March 2018

NMR Structure of the Free Zinc Binding C-terminal Domain of SecA

Structural highlights

1tm6 is a 1 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[SECA_ECOLI] Required for protein export, interacts with the SecYEG preprotein conducting channel. SecA has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.^[1]

Publication Abstract from PubMed

SecA is an integral component of the prokaryotic Sec preprotein secretory translocase system. We report here the solution NMR structure of a fragment corresponding to the C-terminal domain of Escherichia coli SecA. In the presence of Zn2+, the fragment adopts a shortened version of the classic betabetaalpha zinc finger fold. The isolated C-terminal domain shows substantial differences from the X-ray structure of a homologous SecA domain bound to the chaperone-like cofactor SecB. The differences between the structures of the free and bound forms suggest that binding to SecB causes a perturbation of the C-terminal domain's intrinsically favored betabetaalpha fold.

NMR structure of the C-terminal domain of SecA in the free state.,Matousek WM, Alexandrescu AT Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Froderberg L, Houben EN, Baars L, Luirink J, de Gier JW. Targeting and translocation of two lipoproteins in Escherichia coli via the SRP/Sec/YidC pathway. J Biol Chem. 2004 Jul 23;279(30):31026-32. Epub 2004 May 12. PMID:15140892 doi:10.1074/jbc.M403229200
↑ Matousek WM, Alexandrescu AT. NMR structure of the C-terminal domain of SecA in the free state. Biochim Biophys Acta. 2004 Nov 1;1702(2):163-71. PMID:15488768 doi:S1570-9639(04)00216-X

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1tm6"

@@ Line 1: / Line 1: @@
 ==NMR Structure of the Free Zinc Binding C-terminal Domain of SecA==
 <StructureSection load='1tm6' size='340' side='right' caption='[[1tm6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
@@ Line 4: / Line 5: @@
 <table><tr><td colspan='2'>[[1tm6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1TM6 FirstGlance]. <br>
 </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm6 OCA], [http://pdbe.org/1tm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm6 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1tm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tm6 OCA], [http://pdbe.org/1tm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1tm6 RCSB], [http://www.ebi.ac.uk/pdbsum/1tm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1tm6 ProSAT]</span></td></tr>
 </table>
 == Function ==

1tm6

From Proteopedia

Revision as of 08:43, 21 March 2018

NMR Structure of the Free Zinc Binding C-terminal Domain of SecA

Structural highlights

Function

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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