1u8z

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|PDB= 1u8z |SIZE=350|CAPTION= <scene name='initialview01'>1u8z</scene>, resolution 1.50&Aring;
|PDB= 1u8z |SIZE=350|CAPTION= <scene name='initialview01'>1u8z</scene>, resolution 1.50&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
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|LIGAND= <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
|ACTIVITY=
|ACTIVITY=
|GENE= Rala, Ral-a, Ral ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Saguinus oedipus])
|GENE= Rala, Ral-a, Ral ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9490 Saguinus oedipus])
 +
|DOMAIN=
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|RELATEDENTRY=[[1u8y|1U8Y]], [[1u90|1U90]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1u8z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u8z OCA], [http://www.ebi.ac.uk/pdbsum/1u8z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1u8z RCSB]</span>
}}
}}
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[[Category: Nicely, N I.]]
[[Category: Nicely, N I.]]
[[Category: Serrano, V de.]]
[[Category: Serrano, V de.]]
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[[Category: GDP]]
 
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[[Category: MG]]
 
[[Category: gdp]]
[[Category: gdp]]
[[Category: gmppnp]]
[[Category: gmppnp]]
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[[Category: ra]]
[[Category: ra]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:50:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:07:00 2008''

Revision as of 21:07, 30 March 2008

Image:1u8z.jpg


PDB ID 1u8z

Drag the structure with the mouse to rotate
, resolution 1.50Å
Ligands: ,
Gene: Rala, Ral-a, Ral (Saguinus oedipus)
Related: 1U8Y, 1U90


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structures of Ral-GppNHp and Ral-GDP reveal two novel binding sites that are also present in Ras and Rap


Overview

RalA is a GTPase with effectors such as Sec5 and Exo84 in the exocyst complex and RalBP1, a GAP for Rho proteins. We report the crystal structures of Ral-GppNHp and Ral-GDP. Disordered switch I and switch II, located away from crystal contacts, are observed in one of the molecules in the asymmetric unit of the Ral-GppNHp structure. In the other molecule in the asymmetric unit, a second Mg(2+) ion is bound to the GppNHp gamma-phosphate in an environment in which switch I is pulled away from the nucleotide and switch II is found in a tight beta turn. Clustering of conserved residues on the surface of Ral-GppNHp identifies two putative sites for protein-protein interaction. One site is adjacent to switch I. The other is modulated by switch II and is obstructed in Ral-GDP. The Ral structures are discussed in the context of the published structures of the Ral/Sec5 complex, Ras, and Rap.

About this Structure

1U8Z is a Single protein structure of sequence from Saguinus oedipus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Ral-GppNHp and Ral-GDP reveal two binding sites that are also present in Ras and Rap., Nicely NI, Kosak J, de Serrano V, Mattos C, Structure. 2004 Nov;12(11):2025-36. PMID:15530367

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