1v39

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|PDB= 1v39 |SIZE=350|CAPTION= <scene name='initialview01'>1v39</scene>, resolution 1.8&Aring;
|PDB= 1v39 |SIZE=350|CAPTION= <scene name='initialview01'>1v39</scene>, resolution 1.8&Aring;
|SITE=
|SITE=
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene> and <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>
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|LIGAND= <scene name='pdbligand=M7G:7N-METHYL-8-HYDROGUANOSINE-5&#39;-DIPHOSPHATE'>M7G</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polynucleotide_adenylyltransferase Polynucleotide adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.19 2.7.7.19] </span>
|GENE=
|GENE=
 +
|DOMAIN=
 +
|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1v39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1v39 OCA], [http://www.ebi.ac.uk/pdbsum/1v39 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1v39 RCSB]</span>
}}
}}
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[[Category: Hodel, A E.]]
[[Category: Hodel, A E.]]
[[Category: Quiocho, F A.]]
[[Category: Quiocho, F A.]]
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[[Category: M7G]]
 
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[[Category: SAH]]
 
[[Category: methyltransferase]]
[[Category: methyltransferase]]
[[Category: mrna processing]]
[[Category: mrna processing]]
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[[Category: vaccinia]]
[[Category: vaccinia]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 13:57:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:18:54 2008''

Revision as of 21:18, 30 March 2008


PDB ID 1v39

Drag the structure with the mouse to rotate
, resolution 1.8Å
Ligands: ,
Activity: Polynucleotide adenylyltransferase, with EC number 2.7.7.19
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



DC26 MUTANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYLHOMOCYSTEINE AND M7G(5')PPPG


Overview

The specific binding of N7-methylguanine cap analogues to the RNA methyltransferase VP39 was observed through X-ray crystallography, providing a prototypical structure for a complex between a protein and an mRNA 5' cap.

About this Structure

1V39 is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

Specific protein recognition of an mRNA cap through its alkylated base., Hodel AE, Gershon PD, Shi X, Wang SM, Quiocho FA, Nat Struct Biol. 1997 May;4(5):350-4. PMID:9145102

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