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1w4r
From Proteopedia
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|PDB= 1w4r |SIZE=350|CAPTION= <scene name='initialview01'>1w4r</scene>, resolution 1.83Å | |PDB= 1w4r |SIZE=350|CAPTION= <scene name='initialview01'>1w4r</scene>, resolution 1.83Å | ||
|SITE= <scene name='pdbsite=AC1:Dtu+Binding+Site+For+Chain+E'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Dtu+Binding+Site+For+Chain+E'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=DTU:(2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL'>DTU</scene>, <scene name='pdbligand=TTP:THYMIDINE-5'-TRIPHOSPHATE'>TTP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
| - | |ACTIVITY= [http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] | + | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidine_kinase Thymidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.21 2.7.1.21] </span> |
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1w4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1w4r OCA], [http://www.ebi.ac.uk/pdbsum/1w4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1w4r RCSB]</span> | ||
}} | }} | ||
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[[Category: Scapozza, L.]] | [[Category: Scapozza, L.]] | ||
[[Category: Schulz, G E.]] | [[Category: Schulz, G E.]] | ||
| - | [[Category: DTU]] | ||
| - | [[Category: TTP]] | ||
| - | [[Category: ZN]] | ||
[[Category: cytosolic]] | [[Category: cytosolic]] | ||
[[Category: human]] | [[Category: human]] | ||
| Line 40: | Line 40: | ||
[[Category: type ii]] | [[Category: type ii]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:31:09 2008'' |
Revision as of 21:31, 30 March 2008
| |||||||
| , resolution 1.83Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Thymidine kinase, with EC number 2.7.1.21 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
STRUCTURE OF A TYPE II THYMIDINE KINASE WITH BOUND DTTP
Overview
The structure of human cytosolic thymidine kinase in complex with its feedback inhibitor 2'-deoxythymidine-5'-triphosphate was determined. This structure is the first representative of the type II thymidine kinases found in several pathogens. The structure deviates strongly from the known structures of type I thymidine kinases such as the Herpes simplex enzyme. It contains a zinc-binding domain with four cysteines complexing a structural zinc ion. Interestingly, the backbone atoms of the type II enzyme bind thymine via hydrogen-bonds, in contrast to type I, where side chains are involved. This results in a specificity difference exploited for antiviral therapy. The presented structure will foster the development of new drugs and prodrugs for numerous therapeutic applications.
About this Structure
1W4R is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of a type II thymidine kinase with bound dTTP., Birringer MS, Claus MT, Folkers G, Kloer DP, Schulz GE, Scapozza L, FEBS Lett. 2005 Feb 28;579(6):1376-82. PMID:15733844
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