1xur
From Proteopedia
(Difference between revisions)
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|PDB= 1xur |SIZE=350|CAPTION= <scene name='initialview01'>1xur</scene>, resolution 1.850Å | |PDB= 1xur |SIZE=350|CAPTION= <scene name='initialview01'>1xur</scene>, resolution 1.850Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PB5:N,N'-BIS(PYRIDIN-3-YLMETHYL)PYRIMIDINE-4,6-DICARBOXAMIDE'>PB5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1xuc|1XUC]], [[1xud|1XUD]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xur OCA], [http://www.ebi.ac.uk/pdbsum/1xur PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xur RCSB]</span> | ||
}} | }} | ||
| Line 24: | Line 27: | ||
[[Category: Engel, C K.]] | [[Category: Engel, C K.]] | ||
[[Category: Wendt, K U.]] | [[Category: Wendt, K U.]] | ||
| - | [[Category: CA]] | ||
| - | [[Category: PB5]] | ||
| - | [[Category: ZN]] | ||
[[Category: matrix metalloproteinase]] | [[Category: matrix metalloproteinase]] | ||
[[Category: non-zinc binding inhibitor]] | [[Category: non-zinc binding inhibitor]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:54:59 2008'' |
Revision as of 21:55, 30 March 2008
| |||||||
| , resolution 1.850Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1XUC, 1XUD
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Matrix metalloproteinase-13 complexed with non-zinc binding inhibitor
Overview
The paradigm for matrix metalloprotease inhibition combines active site tailoring and catalytic zinc ligation. But, selectivity has been difficult. Now, Engel et al. present novel compounds, completely selective for MMP-13, with a unique binding mode.
About this Structure
1XUR is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Making a new turn in matrix metalloprotease inhibition., Wasserman ZR, Chem Biol. 2005 Feb;12(2):143-4. PMID:15734640
Page seeded by OCA on Mon Mar 31 00:54:59 2008
